The Alzheimer’s-Iron Connection

imageFree iron is a highly toxic substance that in the body promotes inflammation, erodes tissue and can cause metabolic acidosis. Iron is tightly controlled to avoid toxicity within the body by binding it to two proteins, Ferritin and Trans-Ferritin. Ferritin is the storage protein and Trans-Ferritin is the carrier protein.

Alzheimer’s is described as Type 3 diabetes. It is exactly the same as Type 2 diabetes in that it results in insulin insensitivity because of denatured receptor sites caused by inflammation. It’s a lock and key relationship that results in the key(insulin) not being able to fit the lock because the lock’s shape has been  changed.

Unlike type 2 diabetes which affects the whole organism, type 3 diabetes(Alzheimer’s) has an affect only on the brain. This suggests that the cause of Alzheimer’s is a result of inflammation by something in the brain itself.

Iron does not cross the blood/brain barrier easily but over time some does cross. Once in the brain it is even more difficult to remove than it was passing into it and over time it accumulates, and deposits there.

After a long life these deposits become substantial and the induced cascade of inflammation, insulin insensitivity, and Alzheimer’s becomes established. The resulting high levels of glucose as in type 2 diabetes augments the inflammation and supports the disease process of Alzheimer’s Disease in a self-re-enforcing manner.

I have had great success using Inositol Hexa-Phosphate(IP6) to lower my plasma ferritin levels but it is not known if IP6 will cross the blood/brain barrier to chelate iron from the brain.

It is known that green tea catechans do cross this barrier and chelates iron from the brain.

Curing Alheimer’s is a matter of removing the stores of accumulated iron in the cerebral tissue. Only this approach eliminates the root cause of Alzheimer’s Disease.


Excess Iron and Brain Degeneration: The Little-Known Link 

Iron and Diabetes Risk

In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging

Iron Disorders Institute 


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