The Alzheimer’s-Iron Connection

imageFree iron is a highly toxic substance that in the body promotes inflammation, erodes tissue and can cause metabolic acidosis. Iron is tightly controlled to avoid toxicity within the body by binding it to two proteins, Ferritin and Trans-Ferritin. Ferritin is the storage protein and Trans-Ferritin is the carrier protein.

Alzheimer’s is described as Type 3 diabetes. It is exactly the same as Type 2 diabetes in that it results in insulin insensitivity because of denatured receptor sites caused by inflammation. It’s a lock and key relationship that results in the key(insulin) not being able to fit the lock because the lock’s shape has been  changed.

Unlike type 2 diabetes which affects the whole organism, type 3 diabetes(Alzheimer’s) has an affect only on the brain. This suggests that the cause of Alzheimer’s is a result of inflammation by something in the brain itself.

Iron does not cross the blood/brain barrier easily but over time some does cross. Once in the brain it is even more difficult to remove than it was passing into it and over time it accumulates, and deposits there.

After a long life these deposits become substantial and the induced cascade of inflammation, insulin insensitivity, and Alzheimer’s becomes established. The resulting high levels of glucose as in type 2 diabetes augments the inflammation and supports the disease process of Alzheimer’s Disease in a self-re-enforcing manner.

I have had great success using Inositol Hexa-Phosphate(IP6) to lower my plasma ferritin levels but it is not known if IP6 will cross the blood/brain barrier to chelate iron from the brain.

It is known that green tea catechans do cross this barrier and chelates iron from the brain.

Curing Alheimer’s is a matter of removing the stores of accumulated iron in the cerebral tissue. Only this approach eliminates the root cause of Alzheimer’s Disease.


Excess Iron and Brain Degeneration: The Little-Known Link 

Iron and Diabetes Risk

In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging

Iron Disorders Institute 

Iron levels in brain predict when people will get Alzheimer’s


Alzheimer’s predicted by excess cerebral iron accumulation


16 thoughts

  1. Alzheimer’s Disease effects so many people and like so many conditions results in an inflammatory process that triggers autoimmune functions to go array. This is a good read and concise. Heavy metals are everywhere and in some places around the world are abundant in the food chain and water supply. Thank you Seven Spheres.

  2. Do you think that chelation of iron improves or worsens Alzheimers? I can’t tell whether or not you want to chelate iron in the brain (I would imagine not – but the comment on green tea makes me think differently).

  3. My mother lived to 99.6 and we never lost her (to alzheimers or dementia) until we lost her. Others are not so lucky. Their parents live long too, but they lose them in the prime of their golden years. We need to understand and conquer this living death.

  4. There is a long term study conducted in a Scandinavian country that was conducted over several decades. After young women were given histerectomies their plasma iron levels mimicked those of men since they no longer menstruated.
    The consequence was that these women lost their life expectancy advantage over men and died about seven or eight years younger than they would have otherwise.
    Sorry, I saved the article a few ears ago, formatted the computer since and have been unable to find it again. 😬

  5. This is interesting work, for sure. I think there are many factors that play into the development of Alzheimer’s disease but I think your explanation here may be too simplistic. There are other factors including proteins and plaques that develop in the brain, not just inflammation, though I know it is a factor.
    The research that neuroscience is doing right now is coming up with many new ways to look at the disease. The Alzheimer’s Roundtable was released back in late September which also explores this issue, and you may find it interesting.

  6. There are two additional points;
    1. The recognition of Alzheimer’s as type 3 diabetes was answered by speculation like a bacterial infections localized in the brain, but there is no evidence for this. Excess iron fulfills all the requirements of the primary cause of this disease.
    2. A Ketogenic Diet relieves the symptoms of Alzheimer’s but does not cure it. As type 3 diabetes, ketones are an insulin insensitivity independant source of energy for the brain. This provides a non glucose based energy source for energy depleted cells.
    Proteins, enzymes and plaques are the result of this malady so not to confuse them with the cause.

  7. The brain needs cholesterol to function properly. Check out Dr. Berg and Dr. Wallach on Youtube. It’s all over the place, they’re not the only ones that have medical information or can direct one to medical studies. Low cholesterol = ED, early menopause and the alzeheimer’s hoax that provides $ to many pockets, and it has been known for decades. Labels are very important to the insurance industry and those that gain from the labels. AKA the diabetes 3. Iron connection-I will look into that, as new info arises with new technology.

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